Honing In on TMC as the Hair Cell’s Transduction Channel
نویسندگان
چکیده
منابع مشابه
The transduction channel filter in auditory hair cells.
In the first step in auditory transduction, sound-induced vibrations of the stereociliary bundles on the sensory hair cells are converted into electrical signals by opening of mechanotransducer channels. Faithful transduction and hence auditory performance will be limited by the kinetic properties of these channels. We have measured the time course of mechanotransducer currents in turtle and ra...
متن کاملWhat is the hair cell transduction channel?
In contrast to nearly all other sensory systems, the mechanically sensitive ion channel carrying the receptor current into hair cells of the inner ear has not been identified in molecular terms. A number of candidates from at least two different ion channel families have been considered: these include the epithelial sodium channel (ENaC) and acid-sensing ion channel (ASIC) members of the DEG/EN...
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Throughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the cells. The anomalous MS channels are responsible for the reverse-pola...
متن کاملMechanotransduction: The Elusive Hair Cell Transduction Channel Revealed?
A family of transmembrane proteins has been shown to modulate both the calcium permeability and single-channel conductance of the vertebrate hair-cell mechanosensor, implicating them directly in inner ear mechanosensation.
متن کاملFalsification of the ionic channel theory of hair cell transduction
The hair cell provides the transduction of mechanical vibrations in the balance and acoustic sense of all vertebrates that swim, walk, or fly. The current theory places hair cell transduction in a mechanically controlled ion channel. Although the theory of a mechanical input modulating the flow of ions through an ion pore has been a useful tool, it is falsified by experimental data in the liter...
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ژورنال
عنوان ژورنال: Neuron
سال: 2018
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2018.08.013